When oil is discovered in 1920s Oklahoma under Osage Nation land, the Osage people are murdered one by one—until the FBI steps in to unravel the mystery.

Outlaw Jesse James is rumored to be the 'fastest gun in the West'. An eager recruit into James' notorious gang, Robert Ford eventually grows jealous of the famed outlaw and, when Robert and his brother sense an opportunity to kill James, their murderous action elevates their target to near mythical status.

Buffalo Bill plans to put on his own Wild West sideshow, and Chief Sitting Bull has agreed to appear in it. However, Sitting Bull has his own hidden agenda, involving the President and General Custer.

A revisionist western, "Doc" is Frank Perry's attempt to accurately portray the lives and persons of Doc Holliday, Wyatt Earp, and the now-legendary events that took place in the town of Tombstone, starring Stacy Keach, Faye Dunaway and Harris Yulin.