Kapetan Jack Sparrow (Johnny Depp) nađe se na neplaniranom putovanju prema mitskom Izvoru mladosti kada ga žena iz njegove prošlosti (Penelope Cruz) dovuče na palubu "Osvete kraljice Ane", broda omraženoga kapetana Crnobradog.

The eponymous wraith returns to Earth to aid his descendant, elderly Emily Stowecroft. The villains want to kick Emily and her friends out of their group home so that they can build a crooked casino. Good guy Steve Walker gets caught in the middle of the squabble after evoking Blackbeard's ghost.

Honest Robert Maynard finds himself serving as ship's surgeon under the infamous pirate Blackbeard.