Scoob! fortæller historien om, hvordan de bedste venner, Scooby og Shaggy, mødte hinanden og hvordan de, sammen med Fred, Velma og Daphne, startede – den nu berømte – Mysteriebanden. Med hundredvis af eventyr og opklarede mysterier i bagagen, står Scooby og vennerne nu overfor deres største og mest udfordrende mysterium nogensinde: nemlig en sammensværgelse, der planlægger at slippe spøgelseshunden, Cerberus, løs i verden. Mens Mysteriebanden kæmper mod tiden for at stoppe ”hundedommedagen”, opdager de, at Scooby har en hemmelig fortid og en episk skæbne i vente, der er større end nogen nogensinde havde forestillet sig.
A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.
An alcoholic grandfather is seriously ill. His doctor suggests that experiencing a bad scare could cure him. His grandson volunteers to help him.
On their way to Night School, Casper the Friendly Ghost and his pal, Spooky Ghost, pass a zoo, and Spooky has a good time scaring the animals until Casper, posing as the ghost of the scared denizens of the zoo, scares Spooky.
Awaken in his desk office, an intern-office workers trying to get home but somehow he felt something was following him.
After had a biggest lost in his life, a young man felt uneasy when he arrived at his family home, -convinced himself there's was something disturbing lurking here.
After had a biggest lost in his life, a young man felt uneasy when he arrived at his family home, -convinced himself there's was something disturbing lurking here.