Den unge forfatter Paul Varjak flytter ind i en lejlighed i New York og får her den temperamentsfulde og lettere excentriske Holly Golightly som nabo. Hendes livsstil både forvirrer og fascinerer ham. Til de mange fester, hun deltager i, er hun sexet og sofistikeret, men når de er alene sammen, forvandler hun sig til et sødt, men usikkert bundt neuroser. Langsomt forelsker han sig i hende.

En dag under en flugt fra sine kreditorer gemmer den unge manuskriptforfatter Joe Gillis sig i en garage til et palæ på Sunset Boulevard. Her møder Joe den tilbagetrukne stumfilmstjerne Norma Desmond, der vil hyre Joe til at renskrive et comeback, hun har arbejdet på i flere år. Den kyniske og opportunistiske Joe siger ja til det håbløse projekt og er snart fuldstændig i hænderne på Norma. Alt imens følger Normas chauffør Max Von Mayerling tavst begivenhederne fra sidelinien.

Critics and the public say Karen Stone is too old -- as she approaches 50 -- for her role in a play she is about to take to Broadway. Her businessman husband, 20 years her senior, has been the angel for the play and gives her a way out: They are off to a holiday in Rome for his health. He suffers a fatal heart attack on the plane. Mrs. Stone stays in Rome. She leases a magnificent apartment with a view of the seven hills from the terrace. Then the contessa comes calling to introduce a young man named Paolo to her. The contessa knows many presentable young men and lonely American widows.

Soon after being wed, American heiress Lady Pearl Grayston realizes her husband has married her for her money and is keeping a mistress. The two maintain a loveless marriage, a trade-off Pearl accepts in order to gain admittance to her husband's aristocratic social circle. While Pearl pursues her own affair with gigolo Pepi D'Costa, her visiting sister, Bessie, arrives and is appalled when Pearl's arrangement is revealed.