樂壇奇葩真人真事改編！紐約貴婦芙蘿倫絲簡金斯（梅莉史翠普 飾）從小便熱愛音樂及歌唱，期許自己有一天成為當代最偉大的女歌手，五音不全的她一開口唱歌便如魔音傳腦般令人震撼，但自我感覺超良好的她卻覺得自己的歌聲在就像天籟美音、黃鶯出谷。善良的經紀人貝福爾德（休葛蘭 飾）癡癡守護在旁支持著芙蘿倫絲，不願戳破她對於演唱事業的癡心妄想，直到她開口希望在樂壇聖地紐約卡內基音樂廳舉辦售票演唱會，貝福爾德才發現大勢不妙，眼看事情一發不可收拾，貝福爾德該如何告訴芙蘿倫絲殘酷真相，而芙蘿倫絲在一連串的歌唱特訓後，又會以怎樣的歌聲震撼全場？

Paris in the 1920s. Marguerite Dumont is a wealthy woman with a passion for music and the opera. For years, she has performed regularly for a circle of guests. But Marguerite sings tragically out of tune and no one has ever told her. Her husband and her close friends have always encouraged her in her illusions. Things become very complicated the day she gets it into her head to perform in front of a genuine public, at the Opera.

Florence Foster Jenkins is known as "the worst singer of all times" and yet she is a cult figure whose recordings still outsell many contemporary singers. Opera superstar Joyce DiDonato interprets the flamboyant "queen of dissonance". The involvement of the celebrated virtuoso makes it possible to contrast two different musical perspectives and gives viewers a vivid impression of the film's key conflict between inner delusion and external reality.