二十世纪70年代，旧金山出现了一个自称“十二宫”的杀人狂，杀人后，向媒体寄一封信，留下密码、线索，向警方挑衅，多次的阴差阳错使案件陷入僵局，警方渐渐束手无策。连环杀人案件也引起了《旧金山纪事报》的记者罗伯特（杰克•格兰恩哈尔 饰）和保罗（小罗伯特•唐尼 饰）的注意，他们在警察大卫（马克•普法洛 饰）的帮助下，开始调查这一系列的连环凶杀案件，在和“十二宫”杀手斗志斗勇的同时，他们个人的生活也面临了极大的挑战。

An elusive serial killer known as the Zodiac terrorizes the San Francisco Bay in the late 1960s, while detectives aim to stop him before he claims more victims. Based on a true story.

　　影片讲述了哈维无意中发现了多年前连环杀手十二宫自拍的杀人录像，他联系好友决定报警并平分十万美金的悬赏，不料当夜杀手便将他们盯上，一场屠杀即将开始。

A young man who works at a nursing home uses the legendary Zodiac killer's M.O. to kill people who neglect their elderly relatives.

A Christian man dies and goes to hell, but comes back to life and preaches about his experience for Jesus.

Richard Gantz has no chance of paying rent, keeping a job or finishing a movie project. Everything changes when he gets recruited by the aging zodiac killer to make him a film, while collecting "slaves for paradise."

Everyone who enters a crime scene leaves something behind and takes something away. "Something Left, Something Taken" is an animated dark comedy about a vacationing couple's encounter with a man they believe to be the Zodiac Killer.