An insane surgeon's obsession with an actress leads him to replace her wounded pianist husband's hands with the hands of a knife murderer--hands which still have the urge to throw knives.

Wealthy slacker college student Mark, his new girlfriend Sarah, and their friends are invited to a special showing at a mysterious wax museum which displays 18 of the most evil men of all time. After his ex-girlfriend and another friend disappear, Mark becomes suspicious.

A film crew enters a wax museum at night to secretly film a porn parody of House of Wax. By disturbing the displays at night Wax Elvis and Bettie Page come to live to terrorise Manchester and murder innocent citizens.