After a family tragedy turns her life upside down, 16-year-old high school student Tohru Honda takes matters into her own hands and moves out… into a tent! Unfortunately for her, she pitches her new home on private land belonging to the mysterious Soma clan, and it isn't long before the owners discover her secret. But, as Tohru quickly finds out when the family offers to take her in, the Somas have a secret of their own—when hugged by the opposite sex, they turn into the animals of the Chinese Zodiac!

Tohru Honda is 16 year old orphaned girl who gets invited to live in the house of her classmate, the handsome boy Sohma Yuki, and his cousins, 16 year old Kyo and 27 year old Shigure. However, these young men and parts of the rest of their family (both close and distant) hold a curse; if they are hugged by the opposite gender, they transform into animals of the Chinese Zodiac. Everyday is an adventure for sweet Tohru, as she gets to know everyone in the large family better (especially Yuki and Kyo), in both common and bizarre situations. But, the Sohma Family curse is certainly no laughing matter... it also holds horrible cruelty and heartbreak.

Since ancient times, Japan has upheld the tradition of the 12 Zodiac signs. Eto-musumes (Zodiac girls), who have the appearance and behavior of the animals of the Zodiac, are pure hearted messengers who act as a bridge between humans and the gods. Every 60 years, the “ETM 12” tournament takes place in Tokyo’s Akihabara district, where aspiring girls from all over Japan gather for the chance to become the next zodiac sign.