A high school principal is embraced by his community as he continues to lead the school, despite rapidly losing his ability to walk and speak due to the debilitating effects of Amyotrophic Lateral Sclerosis (ALS).

Jail of Flesh, is a documentary that delves into a rare neurological disease. It is fatal, incurable and what provokes it is unknown. Amyotrophic Lateral Sclerosis attacks the motor neurons, those who have this disease gradually lose total ability to move.

Follows the lives of three sisters affected by one having ALS, finding a cure, and the foundation formed to combat the disease, Project ALS.