I det nya kapitlet i MonsterVerse följer vi den hemliga krypto-zoologiska organisationen Monarch, som möter en uppsättning av gudalika monster. Den mäktiga Godzilla kolliderar med Mothra, Rodan och hans ultimata nemesis, King Ghidorah. När dessa uråldriga superfauna vaknar till liv och slåss om herraväldet, riskeras mänsklighetens existens.
A 17th-century Caribbean port rumored to have frequented by pirates rises from the ocean floor, where it came to rest after an earthquake many years before. A scientist wants to study it, some thugs want the treasure alleged to be stored there, a bunch of mutated giant crabs living there attack them all.