Lou (Natasha Lyonne) mistede sin far for lang tid siden, og siden da har hun været fortabt i en evig tåge af stoffer og alkohol. Alle typer rusmidler tages i brug for at holde den virkelige verden på afstand. En dag begynder Lou at vise tegn på graviditet. Lidt besynderligt, for hun har ikke haft sex i lang tid, så hvar er det helt præcist, der vokser inde i hende? Efterhånden som dagene skrider frem, tager hendes smerter til, men Lou forsøger at lade som alt er okay. Det er det bare ikke. Der er noget helt galt med Lou, og hun begynder at miste grebet om virkeligheden.

A man who struggles with the effects of epilepsy and heavy medication reconciles about his choices.

As a result of the 2008 documentary"Generation Rx," thousands of people wrote director Kevin P. Miller to share their experiences on psychiatric drugs. Miller combines their gripping tales with the latest mental health research, science, and medical health perspectives.

Filmmaker Judith Helfand turns the camera on herself to document her battle with cancer caused by DES, a drug prescribed to her mother during pregnancy. Refusing to confine the tears, rage, laughter and hope to dinner table conversations, Helfand invites us to witness her personal journey from radical hysterectomy patient to vocal opponent of toxic exposure. From her suburban home to the halls of Congress, the intensely private becomes widely public, and an American family is transformed and strengthened.