La fuite commence au Colisée. Francesco Totti, Costantino Della Gherardesca, Fedez et Luis Sal, Diana Del Bufalo et Cristiano Caccamo, Claudio Santamaria et Francesca Barra sont en cavale pendant 14 jours. Chacun d’entre eux va essayer de fuir la capitale, mais une équipe de "chasseurs", composée d’anciens officiers de police, de criminologues et de hackers éthiques, feront tout pour les trouver.

The Earth, our planet, is a magnificent and diverse world, filled to the brim with life. But life, in all its forms, cannot exist except within a very specific set of rules – among many, to be alive means to breathe, to breed, to sense one’s environment, and importantly – to and nourishment, in whatever form fits. Out in the wild, it’s eat or be eaten, and few escape this one law that governs all. The epic and eternal battle of predator vs. prey has moulded and shaped all life on Earth and resulted in a fierce array of weaponry and masterful set of skills. Deadliest Hunters takes a closer look at some of the animals that have led the way in refining their skills as masterful huntsmen.