Razmažene odrastanjem u sigurnosti njujorškoga zoološkog vrta, naviknute na redovito hranjenje, brigu i oduševljenost razdraganih posjetitelja, četiri će se životinje, koje pojma nemaju o tome kako život u divljini doista izgleda, nakon svoga bijega u slobodu neugodno iznenaditi. Osjećajni lav Alex (Boris Mirković), živahna zebra Marty (Ozren Grabarić), neurotična žirafa Melman (Drago Utješanović) i drski nilski konj Gloria (Zrinka Cvitešić) najbolji su prijatelji i najveće zvijezde zoološkog vrta, no kada jedan od njih nestane iz svoga kaveza, ostali ga kreću tražiti, a putovanje svih završit će u dalekoj Africi, i to na Madagaskaru.
2035. godine osuđeni James Cole nevoljko se dobrovoljno vratio u prošlost kako bi otkrio podrijetlo smrtonosnog virusa koji je izbrisao gotovo cijelo stanovništvo zemlje i prisilio preživjele u podzemne zajednice. Ali kad Colea pogrešno pošalju u 1990. umjesto u 1996., uhićen je i zatvoren u mentalnu bolnicu. Tamo upoznaje psihijatra dr. Kathryn Railly i pacijenta Jeffreyja Goinesa, sina poznatog stručnjaka za viruse, koji možda drži ključ misteriozne nevaljale skupine, Armije 12 majmuna, za koju se smatra da je odgovorna za oslobađanje od ubojite bolesti.
A sinister corporation loses control of a house cat infected with a genetically-engineered virus. The death-toll rises during the mutant feline's rampage, and eventually, it finds its way on board a ship of a criminal king-pin.
A zoo veterinarian gets caught up in a grisly adventure as she finds herself leading the city-wide hunt for a monstrous lion terrorizing the Dutch capital of Amsterdam.
A wildcat escapes from the zoo, disguises herself as a skunk to fool her pursuers, but that only attracts lovestruck Pepe le Pew.
Panic grips a small community after a tanker truck crashes through a fence at a wild animal park, freeing dozens of dangerous beasts.
A tiger escapes from a circus truck as it passes by a small town, and hides itself in the surrounding woods. This throws the town into a panic and everyone wants the animal killed immediately, except for the daughter of the sheriff. She wants to capture the tiger and put it in a zoo, thereby saving the tiger's life. Her determination starts a nationwide campaign among children to raise the money to buy the tiger from the circus, but first, she, her father and an Indian tiger trainer must find the tiger before the National Guard do, who have orders to kill it on sight.
A young boy lets the animals out of their cages at the Zoo, to set them free, but the animals start taking over the town.
In this Pete Smith Specialty short, two lion cubs escape from the zoo and go on an adventure.