David Mann kører stille og roligt på en amerikansk landevej med de tilladte 80 kilometer i timer. Han overhaler en lastbil, der inden længe igen dukker op i bakspejlet ubehageligt tæt på. Lastbilen presser hele tiden David mere, der på sin side reagerer med en blanding af frygt og vrede, og der udvikler sig en duel på liv og død mellem de to bilister.

Due to his poor health, Dante Kathlego loses his job, which causes some friction between him and his wife, Alisha. She still decides to travel to Melbourne to promote Dantes new novel. While Alisha is away, Dante is unable to drive so he enlists his best friend Mike to be his driver and companion, however; Mike is reckless, known to take risks and put himself, and others, in serious danger. Meanwhile, in Melbourne, Alisha meets the rich, handsome and dangerous Nate who convinces her to abandon her children and family. This starts a chain reaction of violence, death, heartbreak and trauma where no one is left unharmed by these irreversible choices.