In December 1941, Czech soldiers Jozef Gabčík and Jan Kubiš parachute into their occupied homeland to assassinate Nazi officer Reinhard Heydrich.

With the Third Reich at its peak in 1942, the Czech resistance in London plans the most ambitious military operation of WWII – Anthropoid. Two young recruits are sent to Prague to assassinate the most ruthless Nazi leader – Reinhard Heydrich, head of the Reich Security Main Office, the Gestapo and the architect of the Final Solution.

The plot begins in the Soviet Union showing first efforts to establish the Czechoslovak legion in 1942. The film also shows the assassination of Heydrich and the subsequent annihilation of Lidice. The main topis of the film is battles with German troops for Sokolovo.

After an attack against the guard of the Third Reich, Nazi repression intensifies, and the Czechoslovakian resistance's organized sabotage in an aircraft factory leads to Gestapo shootings.