When a former BlackRose cartel assassin deliberately betrays them by refusing to complete her mission, the cartel orders her execution. Unbeknownst to them, she fakes her own death and is able to create a new life of her own. When the cartel discovers she is alive, the hunter becomes the hunted as she fights to get revenge on those who took her new life away from her.

To hårdkogte teenagepiger fra New York, spillet af Saoirse Ronan og Alexis Bledel, har slået sig på overfald og mord. For at skaffe penge til kjoler (af den type som deres yndlingspopidol Barbie Sunday går i) beslutter de sig for at begå et nyt overfald og ender i lejligheden hos en kræftramt, livstræt stakkel (James Gandolfini), der faktisk tigger dem om at slå ham ihjel af medlidenhed. Det udvikler sig til en uventet situation for pigerne.