Filmen Antrum er produceret i 1970'erne af to brødre, som dokumenterede et okkult ritual, men pludselig forsvandt den. I 1988 dukkede den op på filmfestival i Budapest. Samtlige 56 tilskuere omkom, da der opstod brand under visningen af filmen. Flere mystiske dødsfald har kunnet sættes i forbindelse med filmen, inden den sidste kopi til sidste forsvandt under optøjer i en biograf i San Francisco. Nu har man fundet negativerne til filmen, samt en filmrulle, der hidtil har været bortkommet. Endelig er den dødeligste film nogensinde parat til at blive udsendt - igen!
When a couple of American young adults fly to Israel to visit the city of Jerusalem, a biblical nightmare falls upon the city.
Stuck in a dead end town, young James kills time with his druggie friends, engaging in debauched chemical intake to the point of unconsciousness, until he meets Sara, a sweet new arrival to their group. However, Sara wants James to take her further into the world of narcotics experimentation (just as James was contemplating abandoning this lifestyle), and she also wants him to introduce her to the sinister local legend of Toad Road, a spot deep in the forest that is apparently home to the Seven Gates of Hell.