在歷經一連串可怕的謀殺案之後，辛妮普斯考變得更堅強，但是這個惡夢並沒有結束。一部叫「刺殺」的電影上映之後，平靜的校園又開始發生一連串十分恐怖的命案。
繼上一次鬼臉殺手大開殺戒之後，四名逃過毒手的倖存者決定離開伍茲柏勒鎮，展開他們人生的全新篇章。在這部全新的《驚聲尖叫6》一片中，梅莉莎巴雷拉（珊曼卡本特）、潔絲敏莎懷布朗（敏蒂米克斯馬汀）、梅森古丁（查德米克斯馬汀）、珍娜奧蒂嘉（塔拉卡本特）、海蒂潘妮迪亞（可碧里德）以及寇特妮考克絲（蓋兒魏德斯）再度飾演他們在這個電影系列中的角色，這次加入的全新演員陣容則包括傑克查恩、亨利茲尼、莉安娜莉貝雷托、德莫麥隆尼、黛文尼科達、東尼雷佛羅里、喬許塞嘉拉以及薩瑪拉威明。
曾被一連串殘酷的殺人事件蹂躪的寧靜小鎮伍茲柏勒，事隔了25年，一不明殺手再度戴上鬼臉面具，對一群青少年展開虐殺，迫使小鎮居民重新面對過往的秘密。
城裡發生一連串針對女性的謀殺案，這些女性死後都被打扮成天使的模樣。因為做案手法與五年前遭逮捕的連環殺人魔「藝術家」極為相似，為了抓到這名模仿犯，警探傑克和瑪麗決定前往監獄尋求藝術家本人的協助。然而，隨著調查的進行，兩人逐漸意識到這不是普通的謀殺案……。
如果只有88分鐘挽救自己的生命... 你要如何揪出那個潛伏在你身邊的殺人兇手？ 大學教授傑克葛蘭博士（艾爾帕西諾飾），是個權望重的犯罪分析學專家，除了授課，他不時受僱於FBI擔任罪犯的精神鑑定專家，為法庭提供分析與意見。 就在就在一個連續殺人犯即將被處決的前夕，傑克接到神秘仰慕者的來電，並傳來一則驚人的訊息，告訴他只剩88分鐘可活！除此之外，一連串似曾相識旳殘酷謀殺案也在不斷上演。 面臨生死交關的這最後８８分鐘中，傑克開始檢視生命中的過客與可能的嫌疑犯，究竟這個瘋狂殺手準備了什麼樣的死亡計劃等著他？潛藏在他週遭的殺手又會是誰的化身呢？會是他的同事？是舉止怪異的問題學生？還是與他有過一夜情的助教，又或是某個擦身而過的陌生人？他該信任誰？時間一步步逼近，他又該如何應對？
After 6 years of brutal murders, the West Yorkshire Police fear that they may have already interviewed The Ripper and let him back into the world to continue his reign of terror upon the citizens of Yorkshire. Assistant Chief Constable of the Manchester Police, Peter Hunter, is called in to oversee the West Yorkshire Police's Ripper investigation and see what they could have missed.
Agatha Sayers best-selling novel becomes her worst nightmare when her daughter is abducted in a copycat scenario tangled with an obsessive assistant intent on stealing her identity.
Following her breakout success in a killer clown horror flick, Bowie finds herself held hostage by an unhinged fan determined to recreate the film's fatal plot.
A young man who works at a nursing home uses the legendary Zodiac killer's M.O. to kill people who neglect their elderly relatives.
While indulging his appetite for the grim and gruesome by patronizing a voyeuristic Web site that's based in a house where a serial killer once lived, a hearing-impaired boy begins to suspect that the site's violence is more than just make-believe.
A moderator on an internet video-sharing platform stumbles across a potential snuff film ring hidden in the depths of the site's content. Are these gruesome videos merely a morbid work of shock-value fiction, or something all too horribly real?
When a psychotic killer escapes from an insane asylum and goes on a killing spree, the SWAT team is sent out to track him down.
Two detectives team up to investigate several murders that they think are linked together. When the latest murder and a mission person report happen on the same day they question if they have a copy cat on their hands.