Drug lord Alonso Marroquín escapes from a Mexican prison in an attempt to go into hiding. A US military secret experiment goes wrong and the elite unit from the Mexican Police that is after Marroquín gets infected, creating a new zombie species. The Army and the zombies end up at the drug lord’s hideout and a battle for human survival begins.

Based on a true story and the book, At the Devil's Table: The Untold Story of the Insider Who Brought Down the Cali Cartel by award-winning investigative reporter William C. Rempel, En la Boca del Lobo follows the series of events that ultimately lead to the dramatic downfall of Colombia’s infamous Cali drug cartel. The story centers on Ricardo Salgado, an engineer and soldier who rises ranks and became in charge of the security of the godfather of the Cali Cartel, one of the largest criminal organizations in the world and rival of the Medellin Cartel.

A survival story from the perspective of three different characters - a Silicon Valley Executive who gets back to Mexico, an ex-Mexican Navy who is determined to get into the United States, and an El-Paso detective who battles his demons.