Quintuplets is a quirky ensemble comedy about the trials and tribulations of two parents raising 15-year-old quintuplets in a three-bedroom home.

Det er Thanksgiving, og familien Busby hjælper overlevende fra orkanen Harvey. Adam og Danielle inviterer folk, der ikke har andre steder at tage hen, til at spise hos dem.

When Oliva and Elzire Dionne have quintuplets in rural 1930s Canada, news of their uncommon family spreads like wildfire and steps up local tourism, thanks in part to an opportunistic town doctor who uses the children to enhance his own celebrity.