Michael Stone is een goeroe op het gebied van klantvriendelijkheid, maar weet in zijn eigen leven ironisch genoeg geen contact te leggen met de mensen om hem heen. Het sociale isolement waarin Michael zich bevindt wordt steeds merkbaarder.
Huishoudster Dolores wordt beschuldigd van de moord op haar vervelende en veeleisende werkgeefster, bij wie ze al jarenlang in dienst was. Door deze gebeurtenis wordt ook de dood van haar man, twintig jaar geleden, weer opgerakeld en rechercheur John Macky is vastbesloten Dolores dit keer wel voor moord achter slot en grendel te krijgen.
By following the lives of five Japanese individuals this documentary explores the problem of depression in Japan and how the marketing of anti-depressant drugs has changed the way the Japanese view depression. Marketing of anti-depressants did not begin in Japan until the late 1990s and prior to this, depression was not widely recognized as a problem by the Japanese public. Since then, use of anti-depressants has sky-rocketed and use of the Japanese word "utsu" to describe depression has become commonplace, having previously been used only by psychiatric professionals.
Following her boyfriend Felix's attempted suicide, Katherine attempts to bring him back to his normal way of life. However, after discovering a bottle of pills in Felix's possession, a confrontation emerges, making them question whether or not they can return to the way life had been before.