An endocrinologist in a dysfunctional marriage with an aging, alcoholic wife journeys to Africa seeking a drug that will restore youth.

Alex is intersex. Although he has XY chromosomes, his sex is ambiguous. When Alex was an infant, his mother authorised genital reassignment surgery, and he was thereafter raised female. Now Alex is an adult, and he is consumed by feelings of anger and loss. After meeting other "XY women" and doing a lot of soul-searching, he decides he wants to live as a man.

Davina was 44 and felt like she was losing it - hot flushes, depression, mental fog. Now she tells her menopause story, busting midlife taboos from sex to hormone treatment.