Transylmania se centra en un grupo de estudiantes que realiza un viaje hasta Rumania a una universidad situada en un castillo. Una vez allí se verán envueltos en una trama vampírica donde un legendario vampiro intenta recuperar una caja de música que tiene atrapada dentro de ella el alma inmortal de su amante con la que pretende resucitarla.

A nurse arrives at a small town to discover that the blood supply at the hospital is being raided by a small group of vampires.

Felicia and Calvin are two 'vampires' living in a desolate Long Island where things are tolerable...Until the local blood bank amps up security measures and their hunt for the red stuff sends them down a rabbit hole of desperation and decadence. Their humanitarian methods of obtaining their sanguine drug soon go out the window when they are faced with the reality of their situation. Once blood has been drawn, the scenario worsens until an all-out massacre is not far off and the maladjusted addicts must consider their rather grim fate, as a couple and as the monsters that they have become.