When disillusioned Swedish knight Antonius Block returns home from the Crusades to find his country in the grips of the Black Death, he challenges Death to a chess match for his life. Tormented by the belief that God does not exist, Block sets off on a journey, meeting up with traveling players Jof and his wife, Mia, and becoming determined to evade Death long enough to commit one redemptive act while he still lives.

William Parrish (Sir Anthony Hopkins), media tycoon, loving father, and still a human being, is about to celebrate his 65th birthday. One morning, he is contacted by the inevitable, by hallucination, as he thinks. Later, Death enters his home and his life, personified in a man's body: Joe Black (Brad Pitt) has arrived. His intention was to take William with him, but accidentally, Joe's former host and William's beautiful daughter Susan (Claire Forlani) have already met. Joe begins to develop certain interest in life on Earth, as well as in Susan, who has no clue with whom she's flirting.

Keith is a Japanese twenty-something who is followed by Death in various disguises. When he finally faces her, Death tells him that he has only 12 hours to live and he needs to make the most of it

Death takes a human form and visits Earth to try to find out why humans want so desperately to cling to life. He unexpectedly falls in love with a beautiful young woman.