When scientists use eco-terrorism to impose their will on the world by affecting extremes in the weather, Intelligence Chief Cramden calls in top agent Derek Flint.

Flint is again called out of retirement when his old boss finds that he seems to have missed 3 Minutes while golfing with the President. Flint finds that the President has been replaced by an actor (Flint's line [with a wistful look] is "An Actor as President?") Flint finds that a group of women have banded together to take over the world through subliminal brainwashing in beauty salons they own.

Dead on Target is the third and final film in the Our Man Flint movie trilogy. The film originally aired on ABC on March 17, 1976. The TV movie was also a pilot for a possible weekly series, but it did not get good enough ratings to warrant such, and Dead On Target became the last Derek Flint movie.