En politisk familiedrama, som tar sted i Firenze i begynnelsen av 15-hundretallet. Cosimo de' Medici må rydde opp i rotet av hans super velstående bank dynastiet, etter at hans far Giovanni plutselig dør.

The name Borgia stands for betrayal, intrigue and corruption in the Vatican, which was the center of the world during the Renaissance.

Når kongen av Frankrike ankommer Napoli og situasjonen roer seg i Roma sverger Rodrigo hevn på sine motstandere. Han forgifter kardinal Della Rovere, som overlever, men paven får snart større problemer når pesten bryter ut i Napoli.

In the 16th century, Arte, a delightful young lady from an aristocratic family, dreams of being an artist and contributing to the renewal of civilization. However, with her father's death, she ends up losing the only person who believed in her passion for art. Now she is expected to marry a nobleman and live as a refined housewife without disgracing her family name. Reluctant to accept her fate, the headstrong Arte steps into the streets in search of a master artisan to take her on as an apprentice.

But no one believes that women are capable of fine craftsmanship, so none are willing to accept her. Luckily, a renowned artisan by the name of Leo is persuaded to take her as his disciple since he has none anyway. And thus, Arte's new life begins, far from the comfort of her noble upbringing. As an apprentice, she must earn her keep while tackling various challenges along the difficult path to becoming a full-fledged, master artisan.