El Capo, the most wanted drug dealer in Mexico, has been intercepted while hiding with his trusted men, his wife and his lover. During his escape, he declares war on the government and his own past.

Aurelio Casillas is a boy who aims high in life; he becomes close to Don Cleto, a dangerous criminal; together they build an empire, but also are met with an inevitable encounter with destiny.

Based on a true story and the book, At the Devil's Table: The Untold Story of the Insider Who Brought Down the Cali Cartel by award-winning investigative reporter William C. Rempel, En la Boca del Lobo follows the series of events that ultimately lead to the dramatic downfall of Colombia’s infamous Cali drug cartel. The story centers on Ricardo Salgado, an engineer and soldier who rises ranks and became in charge of the security of the godfather of the Cali Cartel, one of the largest criminal organizations in the world and rival of the Medellin Cartel.