A legendary and friendly creature named Nessie lives happily in a small pond with her friend MacQuack, a rubber duck. When a rich developer takes the pond and land surrounding it to build a miniature golf course, Nessie is forced to search for a new home.
When Rex finds himself left behind in the bathroom, he puts his limbs to use by getting a bath going for a bunch of new toy friends.
Four low-ranking astronauts are stuck together on an orbital Sanitation Station after they bring a mysterious device aboard their ship and all life on Earth disappears. Little do they know they are about to come under attack by a mutating rubber duck named Gary, who wants to open a portal to his evil dimension and take over the Universe.
Lucky, a small rubber duck (voiced by Christian Borle), prepares to leave the toy factory where he was born to be shipped to the store when, because of Code S (a faulty whistle), it is immediately trashed. By dint of pugnacity, he still manages to return a box of toys ready to board a boat. New twist of fate: Lucky inadvertently pass overboard! Then he will have to face all the dangers always pursuing the same goal: to find the perfect home.