Folkene bag "Toy Story" er klar med en ny animationsfilm. Denne gang handler det om livet som myre. "Græsrødderne" følger myreflokken og specielt outsider-myren Flik, der må kæmpe en brag kamp for at tjene den onde græshoppe fører, Hopper og hans håndlangere. Skæbnen vil, at Flik drager ud i verden for at hente hjælp blandt de større insekter, men ender med at alliere sig med en flok afdanket cirkusartister. På bedste Disney manér sejrer det gode mod det onde, og outsideren bliver en helt blandt flokken.
Begær og magi tørner sammen i tre fabler, der foregår i hver sit eventyrrige. En frigid dronning indgår en djævelsk pagt for at få et barn. En lidderbuks af en konge forelsker sig i lyden af en smuk kvindestemme, men ved ikke, at den tilhører en grim, gammel kone. En anden konge ønsker at finde sin datter et passende parti, men distraheres skæbnesvangert af et højst usædvanligt kæledyr.
I en lille by forsvinder børnene i drastisk tal. Krank, en gal videnskabsmand, kidnapper dem med hjælp fra en religiøs sekt, og forsøger at stjæle deres drømme. Da sekten kommer til at tage gøgleren One's lillebror, begynder tingene imidlertid at gå i den gale retning for Krank. One iværksætter en eftersøgning, og får snart følgeskab af en lille pige fra byens kriminelle børnebander. I et sært univers fyldt med forvredne skæbner og videnskabelige fabler trænger One og pigen Miette langsomt frem mod Kranks skjulested.
John Pettibone (Droopy), a dog whose love of Dixieland music is not appreciated by those around him, has a lucky meeting with Pee-Wee Runt and his All-Flea Dixieland band at the circus.
A flea sets up its new home in the fur of a sleeping dog.
The "Flea" is a handwritten little newspaper written, edited and published by Ilias, a determined twelve year-old schoolboy who lives in a remote village in the mountains near ancient Olympia. His efforts go largely unappreciated by his elders, who tease him and nickname him "The Flea", and his concerned parents are convinced his preoccupation with his newspaper will distract him from more serious studies and forbid him to continue it. Ilias' only allies are a quixotic eccentric and a sensitive schoolgirl. The villagers' scoffing at Ilias' ambitions changes to admiration when an Athenian journalist shows up to do a story on Ilias. He becomes disheartened, however when he realizes much of their enthusiasm stems from hopes for increased tourism spurred by his fame and he distrusts the journalist's motives as well.
A dog lives in harmony with its flea Homer, until Homer spots a lady flea on a passing dog and relocates.