Podvigi posebnih agentov FBI Foxa Mulderja in Dane Scully, ki sta leta 1992 dodeljena projektu Dosjeji X: raziskujeta marginalizirane, nerešene, nepojasnjene in paranormalne primere. Mulder verjame v obstoj nezemljanov in paranormalnega, medtem ko je Scully čisti skeptik, zadolžena za znanstveno analizo Mulderjevih odkritij, ki ovržejo Mulderjevo delo in ga tako vrnejo k običajnim primerom.

A recently unearthed repository of materials formerly classified by the secret government....The Phenomenon Archives.

This series covers the taboo subjects which have had light shed on them by pouring over the materials in this repository.

Set within a hospital, located on the outskirts of town, mysterious phenomenons occur in sequence around a nurse. The nurse is suspected as the cause for some horrible cases and finds herself in danger.