Even though Sam's father is hardly ever home because he is often away on business trips, he is able to connect with his son by teaching him how to pack a suitcase.

Thelma, who came to Hollywood from Joplin to be a star, is ready to go home. She and her pal Patsy are packing up and packing it in. Then, through Patsy's deviousness, Thelma gets a call to come to the studio immediately to audition for a costume drama.

Kyle and Jen, estranged siblings, travel from New York City to rural Pennsylvania to pack up the home of their recently deceased mother. While there, they make a discovery that turns their world upside-down. A Picture of You is a serious movie about life that gets sideswiped in the supermarket parking lot by a funny movie about death. It’s a story about family, loss, secrets, letting go, and starting anew.