Set in a near future where AI is all the rage and nature is becoming a distant memory, Rachel and Alvy are a New York couple ready to take their relationship to the next level and start a family.

Faye attempts to replace her newly deceased husband, Evan, with an android simulant (SIM). Although SIM Evan appears like human Evan in every way, Faye does not feel the same love for SIM Evan as it does for her. SIM Evan tries to win Faye back while at the same time being on-the-run from a government agent chasing down SIMs who have become “conscious” and could potentially be a threat to humankind.

Kenichi and his detective uncle, Shunsaku Ban, leave Japan to visit Metropolis, in search of the criminal, Dr. Laughton. However, when they finally find Dr. Laughton, Kenichi and Shunsaku find themselves seperated and plunged into the middle of a larger conspiracy. While Shunsaku searches for his nephew and explanations, Kenichi tries to protect Tima (a mysterious young girl), from Duke Red and his adopted son Rock, both of whom have very different reasons for wanting to find her.

In the not-too-distant future, androids have come into common usage. However, treating androids on the same level as humans is frowned upon, and there is constant paranoia surrounding the possibility of robots defying humans, their masters. Those who appear too trustworthy of their androids are chided and labeled as "android-holics". Rikuo Sakisaka, who has taken robots for granted for his entire life, one day discovers that Sammy, his home android, has been acting independently and coming and going on her own. He finds a strange phrase recorded in her activity log, "Are you enjoying the time of EVE?". He, along with his friend Masakazu Masaki, traces Sammy's movements and finds an unusual café. Nagi, the barista, informs them that the café's main rule is to not discriminate between humans and androids. While Rikuo tries to reveal Sammy's intentions, he begins to question the legitimacy of the fear that drives humans to regard androids as nothing more than mere tools.