Na época de natal um vôo especial parte com poucos tripulantes e passageiros. Entre eles estão quatro agentes federais e dois criminosos: um serial killer e um perigoso assaltante. Logo após a decolagem, o avião é dominado por um dos criminosos, e, para piorar a situação, uma tempestade ameaça a continuidade da viagem.

The co-pilot and engineer of a passenger jet struggle to keep the plane airborne after a marshal onboard, transporting a murderer to prison, has a heart attack and the killer uses his gun to shoot the captain and blow out the hydraulics.

While on a flight home from Colombia, the plane that Dr. Carrie Ross and her daughter are on is attacked by bullet ants whose sting is the most painful and deadliest on the planet. Joining forces with air marshal Ethan Hart, Dr. Ross, an entomologist, tries desperately to save the flight from disaster. In the end, their struggle brings them closer together and offers the couple hope for the future.