'Nope' volgt enkele inwoners aan de eenzame kloof van het binnenland in Californië. Ze zijn als paardentrainers betrokken bij het maken van een nieuw filmproject. Ze worden vervolgens getuige van een griezelige en huiveringwekkende ontdekking.
A perverse woman "works" on the corruption of a young girl who serves as her maid.
A teenage horse trainer fears she'll lose her beloved horses when the stables where she works is sold.
A girl owns a horse, and hires a boy as a trainer. The horse enters a race and is injured. The boy takes job at another stable and is semi-seduced by the stable siren. The girl finally rehabilitates the horse then enters it in a big race.
A woman whose body and mind are worn out. A man who could never love a woman because of his distrust of his wife. The two people meet by chance and live a platonic life together on a farm, which gradually heals the emotional wounds of the man and woman, but one night, a shocking event that happens in the horse stable causes the woman to be shocked again. It drags her into a quagmire of momentary pleasures of the flesh.