Смештена у данашњи Вашингтон, Кућа од карата је прича о Франку Андервуду, немилосрдном и лукавом политичару и његовој супрузи Клер која се неће зауставити ни пред чим да би све освојила. Ова опака политичка драма продире у сеновити свет похлепе, секса и корупције у модерном Вашингтону.

Mackenzie Allen has a lot on her plate -- she has twin teenagers, a 6-year-old at home and an ambitious husband at the office, and she is about to become the first female president of the United States. Before that happens, however; Mackenzie, who serves as vice president, has to decide whether or not to go against the dying wishes of the current president, who has asked her to step down and let someone "more appropriate" fill his shoes in the Oval Office. Not only does the president want her to resign, so does the entire party that elected her in the first place. But when the moment of truth arrives, Mackenzie isn't willing to be a mere footnote in history. Instead of allowing her detractors to keep her down, she decides to trust her instincts and accept the most powerful job in the world.

A look into American politics, revolving around former Senator Selina Meyer who finds being Vice President of the United States is nothing like she expected and everything everyone ever warned her about.

A competent secretary and a narcissistic boss fall in love while uncovering a traumatic past that causes them to question whether their feelings are real or the result of a shared trauma.

Lee Young-Joon's family runs a large company and he works as the vice-president of the company. He is smart, rich and handsome, but he is arrogant. His secretary is Kim Mi-So. She has worked for him for years and she is perfect for him, but Kim Mi-So decides to quit her job.

Hidden from the view of the public - and even from the President - there is a top secret agent who is trained and ready to serve, deployed only at the careful discretion of the Vice President.