During the Chinese Revolution in 1949, young Chinese copra trader named Fong-Huan marries Elisa, a young and pretty Filipina. The couples children, Daniel and Linda, were raised in a mixture of Chinese and Filipino-Hispanic tradition. These richly cultured people are the ancestors of a dysfunctional third-generation family whose daughters tell their own stories of joy, struggle, and the complex realities in the life of Filipino Chinese families.

Relationship problems plague a family of siblings in director Catherine O. Camarillo's multilayered indie drama. Businessman Jimmy is reeling from the shock of being dumped by his fiancee, while his sisters cope with their own romantic woes. Leslie can't decide between two eligible bachelors, Annette nurtures a long-distance love, and housewife Claire can't get pregnant.

A culinary romance set in Binondo, where Chinese traditions are still very much observed, Mano Po 5: Gua Ay Di is a touching story of how a young Chinese woman fights for the man she loves. She is doomed by strict family traditions to only wed someone of pure Chinese descent. But Charity finds love where she was not supposed to find it... at least according to her cold-hearted mother. Despite being met with resistance by her traditional Chinese family, most especially her mother, Charity continues her relationship with Nathan. Nathan, on the other hand, proves himself and his love to her by making an effort to learn about her background, culture and language resulting into various mishaps, sometimes comical and other times just plain disastrous. Charity finds solace in the kitchen, her cooking interwoven with the story of her ill-fated romance. Will true love prevail in the end? And will she be able to come up with the perfect recipe for love?

Antonio Chan, a prominent Chinese businessman, has three women in his life Sol, a Filipina; Lu Shui, a Chinese; and Belinda, a Filipino-Chinese. Antonio has children with all three women. A crisis shakes up the over-extended Tsinoy family prompting all the members to re-examine their values, their relationships, and confront issues that they have refused to face all these years.