In the early 16th century, Italy is ruled by the powerful Borgia family, led by César Borgia and his sister Lucrèce. In a ruthless power play, César plots to have his sister’s husband murdered. But without her brother’s knowledge, Lucrèce has taken a strong lover who will challenge the Borgias.

The tiny independent duchy of Ferrara is located between Casare Borgia's Rome and Venice, and Borgia has plans to conquer Venice via Ferrara. He murders his sister's husband and makes it appear that Alfonso D'Este of Ferrara was behind the killing. To avenge herself against Ferrara and D'Este, Lucretia Borgia marries D'Este and intends to poison him. But...she falls in love with him.

In 1500, Duke Cesare Borgia hopes to marry his sister to the heir apparent of Ferrara, which impedes his conquest of central Italy. On this delicate mission he sends Andrea Orsini, his sister's lover and nearly as unscrupulous as himself. En route, Orsini meets Camilla Verano, wife of the count of Citta' del Monte, and sentiment threatens to turn him against his deadly master, whom no one betrays twice...

French silent film pioneer Abel Gance directs this 1935 classic about Lucrezia Borgia, her brother, Cesare. and her father, Pope Alexander VI -- one of history's most ruthless and ambitious crime families.

A playwright descended from the Borgia family becomes a murder suspect.