In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters, also referred to as "Cowboys", chase criminals and bring them in alive in return for a reward.

A house cleaner desperately searches for her husband as a dreaded criminal syndicate dredges up past tragedies and ultimately drives her to violence.

In 1972, the first Black female FBI agent heads to the Southwest and recruits a gutsy getaway driver in a bold effort to take down a growing crime syndicate.