A variety of predicaments arise to distract Dr. Kildare from his wedding to Nurse Mary Lamont.

Intern Kildare heals a millionaire's daughter and tricks Dr. Gillespie into taking a vacation.

Kildare tries brain surgery, advised by Dr. Gillespie, and faces a rival for nurse Lamont.

Following an argument with his young protege, the curmudgeonly Dr. Gillespie dumps Jimmy Kildare in a street clinic, hoping to teach him a lesson. While working there Kildare meets pretty nurse Mary Lamont, and ends up treating a hoodlum with a gunshot wound. He purposely fails to write a report on it, and soon finds himself in a heap of trouble. Who else would come to his rescue but good old Dr. Gillespie?

A medical school graduate takes an internship at a big city hospital, only to be subjected to a rigorous (and sometimes embarrassing) testing of his knowledge by the hospital's top dog, Dr. Leonard Gillespie.

A young doctor gives up big-city success to help his father set up a small-town clinic.

An ice skater sues Kildare (Lew Ayres) for malpractice after his roadside first aid leaves her paralyzed.

Dr. Kildare treats and falls for impoverished ex-con Janet Healy, widow of a bank robber, who can't find her baby. Later she helps Kildare sew up gangster Hanlon in a tavern back room. Kildare pursues Janet and enlists Hanlon to help her; the gangster's solution, not surprisingly, is violent.

Jimmy Kildare's impending nuptials are jeopardized by a diagnosis of possible epilepsy in his fiancee's brother.

Dr. Gillespie supports Kildare's crusade against their hospital's deal with a rival hospital.