《肌膚之侵》透過外星人的視野展現人類的貪婪與自私。史嘉莉喬韓森在片中將化身為外星生物，在蘇格蘭展開公路之旅，以艷麗的外型迷倒眾生，堪稱是好萊塢科幻版《畫皮》。 「她」說著挑逗的話語、扭動性感的身軀誘惑單身男子，進而讓他們陷入致命的圈套，但很快地也意識到自己的良知問題。隨著在地球待的時間越長，「她」更因人類的溫度和行為漸漸起了變化… 史嘉莉喬韓森在片中還將有戴上黑色假髮、外穿毛草，正面卻一絲不卦的戲碼，尺度遠比以往作品更大膽。

An isolated house is too remote for a lone servant, who leaves a note, quietly exits the back door, and puts the key under the mat. Left alone in the house is a mother and her infant. A tramp has watched the servant leave and begins to skulk. When the lady of the house sees him outside as he discovers the key, she's terrified and desperately phones her husband, who's at work in town. He jumps into a car that's idling in front of his office and races toward home, the car's owner, and police, in hot pursuit.

Frank, a gay school teacher, has a very active sex life and an interest in making films. One evening, he meets Bernd and they become lovers. But while Bernd is attentive and caring, Frank gets bored and continues his polymorphously perverse ways.

Professor Clyde is on the lookout for a nightshirt bandit prowling the college campus.