Kawauchi Miyabi was once a promising neurosurgeon, but an accident caused damage to Miyabi's brain. She is unable to remember the past 2 years of her life and she will forget everything that happened today when she wakes up the next day. She has all but given up on becoming a doctor and works as an assistant nurse. One day, Neurosurgeon Sanpei Tomoharu appears in front of her. He is known as an eccentric person. Sanpei Tomoharu guides Kawauchi Miyabi at his own pace, regardless of her will. This actually helps Kawauchi Miyabi as a doctor and a patient. The mystery hidden in her missing memories is gradually revealed, which contains a secret.

3 lbs is a drama that aired on CBS from November 14 to 28, 2006, replacing the cancelled series Smith. The show itself was then canceled three weeks later due to poor ratings. The title refers to the fact that the average human brain weighs approximately three pounds. The show follows the medical careers of prominent brain surgeon Doctor Douglas Hanson and his protégé, Jonathan Seger.

The show was promoted as, "The next great medical drama." The theme song is "Calling All Angels" by Train. Eight episodes were made, and the five episodes that did not originally air in the United States are available on Amazon Unbox.

The program filmed in New York City at the request of Tucci, who didn't want to be away from home to make the series.

When the pilot was originally filmed Dylan McDermott played Dr. Doug Hanson, and Reiko Aylesworth played Dr. Adrienne Holland.

Documentary series which follows patients at the Walton Centre in Liverpool as they undergo brain surgery.