Doktor Michael Hfuhruhurr, którego nazwiska nikt nie potrafi wymówić, jest najlepszym neurochirurgiem na świecie. Pewnego dnia pod koła jego samochodu wpada piękna Dolores Benedict. Doktor ratuje dziewczynie życie i zakochuje się w niej, niestety, bez wzajemności. Dolores godzi się jednak na ślub, ponieważ lekarz jest bardzo zamożny. Małżeństwo jedzie na konferencję do Wiednia, gdzie Hfuhruhurr poznaje tajemniczego doktora Alfreda Necessitera.

In 19th century England, a noted brain surgeon rescues a former student from being hanged on a false conviction for murder, and spirits him away to an ancient, repurposed abbey far in the countryside. There, he connives his pupil into assisting him in mapping the functions of the various parts of the human brain, using living subjects who are under a terrible animation-suspending drug called "black sleep". Subsequently, the student, along with the daughter of one of the subjects, discover that most of these subjects have survived but are being kept in a dungeon-like cellar, in various stages of physical and mental derangement...

University professor George Kingsley is struck by gangsters while crossing the street, leaving him with brain damage and one of the gangsters, Cannon, paralyzed. Kingsley's friend Dr. Sovac attends to both men, and when Cannon offers him a reward for aiding his recovery, Kovac transplants part of Cannon's brain into the dying Kingsley's skull, creating a dual personality.

An American doctor gets caught in the middle of a revolution when he's forced to operate on a South American dictator.

A young wife wants to have children, but her husband neglects her. She confides her longings to a handsome brain surgeon. Complications ensue.

We follow neurosurgeons Clemens Dirven and Arnoud Vincent of the Erasmus MC in Rotterdam in this documentary during the treatment of three patients with a brain tumor.