Smallpox plagues Chief Winterhawk's tribe. He seeks cure from the white men, who in turn, in fear of getting the smallpox, kill two of his companions. Winterhawk comes back to kidnap a girl and her brother from the white men's settlement, and thus begins the chase...

When Bigshot Jones gives his unnamed dog to the All-For-One Club, Buckwheat quickly names the canine "Smallpox", inadvertently causing a city-wide panic.

A doctor's already-shaky marriage is tested to an even greater extent when he has to contend with a smallpox epidemic.

Five passengers in a stagecoach are abandoned by their driver in the desert. Trying to survive, they struggle with illness, thirst, hunger, and the threats posed both by one another and the local Indigenous peoples.

In one of his last film roles, legendary B-Western cowboy Sunset Carson roots out the varmints responsible for a false smallpox scare. After arriving in the small town of Quartzville, Carson determines that a crooked lawyer-and-doctor team created a false smallpox epidemic in order to seize a gold mine from an old man and his family. Carson and his friends set out to bring the villains to justice. Al Terry, Pat Starling and Lee Roberts co-star.

Health officials from the World Health Organization link a smallpox outbreak in Europe to oil drilling in the Middle East.

Errol Morris' "Demon in the Freezer" is a short 17-minute documentary about the stockpiles of the smallpox virus that remain stored for research purposes.

This short focuses on the story of Dr. Edward Jenner, who developed vaccination.

Jan De Bar, a young French-Canadian, is sent out from the Hudson Bay Company's post at God's Lake to perform the perilous task of burning the plague-stricken cabins of those who have died of the dreaded smallpox. In one of them he finds Jeanette, a little girl, who, by some miracle, has escaped the plague.

XIXth century brazilian countryside. After losing their daughter and granddaughter to smallpox, an elderly couple sees their faith rot.