Et hold forskere rejser gennem universet i rumskibet Prometheus på en tur, der har til formål at udforske fremmede livsformer i rummet. Da de finder en mørk og mystisk hule (og om muligt en ny livsform), er lykken gjort, men den viser sig at være kort. Forskerholdet ender nu som strandet på en fremmed planet i det mørkeste hjørne af universet, og imens de må kæmpe for deres overlevelse, går det op for dem, at rædslerne ikke blot er en trussel mod dem selv, men en trussel mod hele menneskeheden.

The love affair between poet Percy Shelley and Mary Wollstonecraft Godwin resulted in the creation of an immortal novel, “Frankenstein; or, The Modern Prometheus.”

Malpertuis is the name of an old, rambling mansion which is in reality a labyrinth where characters from Greek mythology are imprisoned by the bedridden Cassavius. He manages to keep them, as well as his nephew and niece, prisoners even after his death, through a binding testament. As Jan, the nephew, unravels the mystery, he discovers that he cannot escape the house because Malpertuis is far more significant than he was led to believe.