A story about two brothers of the same mother but different fathers. "Sam" Kiu Tin-seng and Lo Wai-son separate after growing up together. Over the course of twenty years, with major historical events occurring in the background of their lives, the two brothers face different moral life struggles while living in Hong Kong and Macau.

Between the mysterious Orient, the paradisiacal peninsula of Troia, the urbanity of Setúbal and the placid splendor of Alcácer do Sal, "Jogo Duplo" is a telenovela that will confront dysfunctional families, impossible loves and cultural differences, reflecting on the human condition in all its opposites.