De CIA krijgt na het fiasco met Jason Bourne te maken met een herkenbare dreiging wanneer nog een vervreemde agent ineens boven water komt.

A drug trafficking gang kidnaps the son of a pharmaceutical tycoon. The young man is attracted to one of the girls in the gang, which they will take advantage of to earn his trust. The goal: get their hands on heroin and cocaine from the father's company's laboratories.

By coincidence rather than by design, the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact that reaches far beyond the scientific world. THE SUBSTANCE is an investigation into our troubled relationship with LSD, told from its beginnings to today.