La película se inicia con los créditos finales de The Human Centipede (First Sequence). La cámara se aleja, para mostrar que la película está siendo reproducida en un ordenador portátil por un hombre en la cabina de vigilancia de un estacionamiento. Se trata de un hombre de nacionalidad británica, que sufre de asma, sobrepeso, mediana edad, reducida estatura y enfermedad mental, que se llama Martin.

Two short stories set in Edo during the Shogun era. 1 - During a time when Christians are persecuted vehemently, Iori falls in love with young Christian girl. When she and her family are captured during a raid, his sadistic master takes her as his personal slave to torment Iori, and tries breaking her spirit by means of rape, torture and pure sadism. After Iori refuses to participate any longer he is exiled, but vows to get her back no matter what it takes. 2 - When Sutezo is forced to serve the barbarous master of a brothel in order to repay his debts, he becomes friends with a young girl named Sato in process. Together, they both escape and try to get by on scams and petty theft.

Algunos alumnos y su profesora se encuentran por primera vez en 16 años durante una pequeña reunión de la clase. Pero el feliz encuentro se convierte en una pesadilla en la medida que, uno a uno, van siendo brutalmente asesinados. Viejos resquemores y verdades ocultas salen entonces a la superficie con cada uno de los brutales asesinatos...

Cannibal is based on the true-crime story of Armin Meiwes, the "Rotenburg Cannibal" who posted an online ad searching for someone to volunteer to be mutilated and eaten. Unlikely as it may seem, someone actually replied. The film shows a fictional portrayal of the meeting between the cannibal and his victim/participant, their homosexual relationship, and the eventual mutilation and murder of said victim.

Follow the owners of the infamous "Maison de la petite mort" during their daily work. After the shocking events in part one, you'll never guess what the new owner Monsieur Matheo Maximè is up to. Torturing for money at it's very - worst.

A Sunday walk through the late summer landscape leads not only to a small lake, but also to the abyss of human existence. Dominance and oppression, superiority and humiliation serve for an alleged "incarnation".

Inspired by 70s Horror movies and real crimes, Dead Human Collection is a bloodbath that follows a deranged Serial Killer and his sadistic habits.

After a young teenage girl leaves a summer concert in the mid 90's, she is viciously attacked and abducted by a young man with animalistic-like behavior. Polly awakens confused and frightened in a deserted vacation home where she is then brutally tortured over a 12 hour period.

A young model falls victim to a sadistic cult of sexual slavery, snuff tapes and black magic.