Notorious Baltimore criminal and underground figure Divine goes up against Connie & Raymond Marble, a sleazy married couple who make a passionate attempt to humiliate her and seize her tabloid-given title as "The Filthiest Person Alive".

For the past year or so, brothers Jim and Steve Peters, both ordained ministers, have been traveling around the nation on a mission from God. Convinced that rock and roll is "one of the largest satanic forces in the country," they have been exhorting American kids to build bonfires of albums in public places.

In mid-nineteenth century England the medical establishment does not recognize the value of skilled nurses, cleanliness, nutrition and kindness. Florence Nightingale's heroic measures slowly changes all of this.