A foreign girl arrives to her new apartment. Her three roommates welcome her rather distantly, for no reason at all, and she can smell that there is something going on...Literally. Everyday when she walks out of her room, she notices a strong smell of insecticide that nobody is willing to explain.

While on a flight home from Colombia, the plane that Dr. Carrie Ross and her daughter are on is attacked by bullet ants whose sting is the most painful and deadliest on the planet. Joining forces with air marshal Ethan Hart, Dr. Ross, an entomologist, tries desperately to save the flight from disaster. In the end, their struggle brings them closer together and offers the couple hope for the future.

As a result of nuclear testing, gigantic, ferocious mutant ants appear in the American desert southwest, and a father-daughter team of entomologists join forces with the state police officer who first discovers their existence, an FBI agent and, eventually, the US Army to eradicate the menace, before it spreads across the continent, and the world.