Telling powerful stories in hourlong episodes, TLC follows medical journeys of morbidly obese people as they attempt to save their own lives. The featured individuals - each weighing more than 600 pounds confront lifelong emotional and physical struggles as they make the courageous decision to undergo high-risk gastric bypass surgery. In addition to drastically changing their appearances, they hope to reclaim their independence, mend relationships with friends and family, and renew their feelings of self-worth.

June Shannon ('Mama June') gained fame as the mother of young beauty-pageant contestant 'Honey Boo Boo' (Alana Thompson) on various reality shows. With that notoriety came jokes from comedians and people on social media about her weight. Ending her marriage to Sugar Bear and facing health issues, Mama June wants to slim down so she can start a new life with a new body and, she hopes, a new love.

A miracle happens, Angelica, a student of journalism suddenly loses 50 kilograms overnight.